Guanidine Thiocyanate GMP Excipient

Excipient

ICH Q7 GMP Manufactured Product

Guanidine Thiocyanate

GMP, Excipient
Product Code: GTHI-3220

Minimum Order Quantity: 100kg
Lead Time (if no stock): 3-months

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UNIT SIZE

QUANTITY

100g

500g

1kg

2-5kg

1x5kg

1x10kg

Total

Product Code: GTHI-3220

Suitable for use as a cGMP chemical in pharmaceutical manufacturing processes and products.

Guanidine Thiocyanate is a chaotropic agent. As one of the strongest protein denaturants, it inactivates nucleases more efficiently than Guanidine Hydrochloride. Guanidine Thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms. Higher molarity solutions of Guanidine Thiocyanate irreversibly inactivate RNase. Guanidine Thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.

CAS #: 593-84-0
Formula: NH₂C(NH)NH₂• HSCN
Solubility: 1,420 g/L at 20°C
F.W.: 118.16 g/mol
pH (5%): 5.0 - 7.0

Product Specifications

ANALYSIS

SPECIFICATIONS

Absorbance (1.7M)

280 nm

300 nm

340 nm

< = 0.300 a.u.

< = 0.050 a.u.

< = 0.030 a.u.

Appearance and Color

White Crystals

Assay, Dried Basis

> = 99.5%

Enzymes

DNase

Protease

RNase

None Detected

Identification, IR

Conforms to Reference Standard

Loss on Drying

< = 0.5%

Melting Range

115 - 121ºC

pH (5%)

5.0 - 7.0

Solubility (35%)

Passes Test

Trace Metals

Arsenic (As)

Copper (Cu)

Iron (Fe)

Lead (Pb)

< = 5 ppm

Printable Version

Key Product Features:

The manufacturing of Guanidine Thiocyanate, GTHI-3220 is performed at BioSpectra’s Bangor, PA facility.
Appears as white crystals
Manufactured in accordance with ICH Q7
Manufactured in an enzyme free, hormone free, and animal free environment
Contains no known major food allergens (as defined by FDA and WHO)
The final product and its raw materials are not derived from nor come into contact with animal parts, animal products, and/or animal byproducts or derivatives.
Is not subject to genetic modification
Synonyms: Guanidine Isothiocyanate

Shelf-Life Policy:

Unless otherwise noted on the Shelf-Life Statement and CoA, this product has a 2-year retest date supported by a 3-year ICH Q1 Stability Study (if one is completed).

Storage & Shipping:

Refer to SDS.

Package Sizes:

10kg, 25kg, and 50kg

Bulk GMP Fine Chemicals exclusively manufactured in North America

American Manufactured - FDA Registered GMP Facilities: Parenteral Excipients, GMP Small Molecule Intermediates, GMP Biological Buffers, Parenteral Carbohydrates, GMP Chlorinated Amino Acids, GMP Solutions in Sterile Single Use Packaging and other Reagent & GMP Fine Chemicals.